Technical Comments

Response to Comments on "A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint"

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Science  18 May 2007:
Vol. 316, Issue 5827, pp. 982
DOI: 10.1126/science.1136935

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Weaver and Cleveland and Taylor et al. contend that our data on the involvement of the γ-tubulin ring complex (γ-TuRC) in the spindle assembly checkpoint (SAC) can be fully explained by kinetochore-derived checkpoint signaling. We maintain that (i) the interactions of γ-TuRC with Cdc20 and BubR1, and (ii) the activation of SAC by γ-TuRC depletion, in addition to the abrogation of kinetochore-microtubule interactions, argue for a more complex mechanism of SAC signaling.

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