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Response to Comment on "Tequila, a Neurotrypsin Ortholog, Regulates Long-Term Memory Formation in Drosophila"

Science  22 Jun 2007:
Vol. 316, Issue 5832, pp. 1698
DOI: 10.1126/science.1138579

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Sonderegger and Patthy argue that the trypsin catalytic domains of Drosophila Tequila and human neurotrypsin are not linked by an orthology relationship. We present analyses based both on BLAST (basic local alignment search tool) comparisons and on phylogenetic relationships, which show that these two proteases do share an orthologous region that includes the trypsin domain.

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