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Response to Comment on "Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery"

Science  13 Jul 2007:
Vol. 317, Issue 5835, pp. 197
DOI: 10.1126/science.1141555

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We tested the hypothesis that cortisol-induced release of fetal oxytocin triggers a perinatal inhibitory switch in γ-aminobutyric acid (GABA) signaling. The cortisol analog methylprednisolone did not modify GABA driving force and intracellular chloride concentration in 1-day-old rat hippocampal neurons. Together with the immaturity of the fetal rat hypothalamo-neurohypophysial system, these results suggest that oxytocin in the rat fetal brain is mainly provided by the mother.

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