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Quantitative Mass Spectrometry Identifies Insulin Signaling Targets in C. elegans

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Science  03 Aug 2007:
Vol. 317, Issue 5838, pp. 660-663
DOI: 10.1126/science.1139952

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Abstract

DAF-2, an insulin receptor–like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.

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