Technical Comments

Response to Comments by Timpson et al. and Yu et al.

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Science  24 Aug 2007:
Vol. 317, Issue 5841, pp. 1036
DOI: 10.1126/science.1143658

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The lack of association of the abnormal spindle-like microcephaly associated (ASPM) and Microcephalin (MCPH1) genes with brain size or intelligence described by Timpson et al. has been reported previously, including by our own group. Moreover, as in most studies of selection, our analyses were entirely independent of phenotypic association. We also respond to the previously published comment by Yu et al., which argued that ASPM has not undergone positive selection.

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