Technical Comments

Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"

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Science  14 Sep 2007:
Vol. 317, Issue 5844, pp. 1500
DOI: 10.1126/science.1138956

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Sjöblom et al. (Research Article, 13 October 2006, p. 268) reported many new genes with an apparent significant excess of mutations in breast and colorectal cancer. Reanalysis of their data with more appropriate statistical methods and background mutation rate assumptions reveals that few if any of these genes have significantly elevated mutation rates.

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