Technical Comments

Response to Comments on “The Consensus Coding Sequences of Human Breast and Colorectal Cancers”

Science  14 Sep 2007:
Vol. 317, Issue 5844, pp. 1500d
DOI: 10.1126/science.1138773

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Abstract

Forrest and Cavet, Getz et al., and Rubin and Green describe a variety of statistical methods to analyze the mutational data published in Sjöblom et al. However, their conclusions are inaccurate because they are based on analyses that do not fully take into account the experimental design and other critical features of our study. When these factors are incorporated, their methods provide estimates similar to those we reported and support the conclusion that a large number of genes are mutated at rates greater than the passenger mutation rate.

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