Anatomy of an Immune Response

Science  05 Oct 2007:
Vol. 318, Issue 5847, pp. 13k
DOI: 10.1126/science.318.5847.13k

Intravital imaging techniques allow experimentally induced immune responses to be traced in real time. Nevertheless, the techniques have often relied on the transfer of nonphysiological numbers of artificially labeled immune cells into animals. Khanna et al. (p. 116) report the use of in situ confocal microscopy of the spleen with a sufficient level of resolution to detect fine features of an immune response to a bacterial infection. Endogenous primary and secondary (memory) T cell responses could be compared, revealing unexpected relocalization within the spleen, as T cells underwent activation, expansion, and then migration out to peripheral anatomical sites.

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