Review

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

See allHide authors and affiliations

Science  02 Nov 2007:
Vol. 318, Issue 5851, pp. 761-764
DOI: 10.1126/science.1146484
  • Fig. 1.

    Features of piRNA clusters. Overview of Drosophila chromosome 2 and progressively more detailed view of a major piRNA cluster.

  • Fig. 2.

    Properties and biogenesis of piRNAs. (A) Features of Aub- and AGO3-associated piRNAs in Drosophila. Indicated are the 5′ U bias in Aub-bound piRNAs, the 10A bias in AGO3-bound piRNAs, the 5′ phosphate, and the 3′ O-methylation. (B) Ping-Pong model of piRNA biogenesis in Drosophila. Primary piRNAs are generated by an unknown mechanism and/or are maternally deposited. Those with a target are specifically amplified via a Slicer-dependent loop involving AGO3 and Aub.

Additional Files


  • The Piwi/piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
    Alexei A. Aravin, Gregory J. Hannon, Julius Brennecke

    Supporting Online Material

    This supplement contains:
    Fig. S1
    Table S1

    This file is in Adobe Acrobat PDF format.