Essays on Science and SocietyGE PRIZE-WINNING ESSAY

Why Old World Monkeys Are Resistant to HIV-1

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Science  07 Dec 2007:
Vol. 318, Issue 5856, pp. 1565-1566
DOI: 10.1126/science.1152905

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Premature disassembly of the HIV-1 capsid is caused by the rhesus monkey protein, TRIM5, and a single amino acid change in human TRIM5confers similar anti-HIV-1 activity.