Technical Comments

Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells"

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Science  14 Dec 2007:
Vol. 318, Issue 5857, pp. 1722
DOI: 10.1126/science.1149590

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Kelly et al. (Brevia, 20 July 2007, p. 337) questioned xenotransplant experiments supporting the cancer stem cell (CSC) hypothesis because they found a high frequency of leukemia-initiating cells (L-IC) in some transgenic mouse models. However, the CSC hypothesis depends on prospective purification of cells with tumor-initiating capacity, irrespective of frequency. Moreover, we found similar L-IC frequencies in genetically comparable leukemias using syngeneic or xenogeneic models.

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