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Science  22 Feb 2008:
Vol. 319, Issue 5866, pp. 1118
DOI: 10.1126/science.319.5866.1118

Centrifugal Sample Prep Kits

The new C18, C8, and C4 SpinTip Sample Prep kits contain tips and reagents for reversed-phase solid-phase extraction of peptide and protein samples for electrospray or matrix-assisted laser desorption/ ionization mass spectrometry. They are particularly useful when runs of larger amounts of solution are involved; they can process sample solutions of up to 1 mL and 200 mg peptide/protein. Research applications of the kits include effective desalting and detergent removal from biomolecule samples and cleanup of peptides from in-gel digested proteins or of proteins electroeluted from polyacrylamide gels.

Protea Biosciences

For information 877-776-8321

Two-Dimensional Electrophoresis System

A two-dimensional electrophoresis system offers the highest focusing voltage available for the first dimension and has an easy-to-use, highly reproducible second dimension separation tank. The complete system includes the IEF100 First-dimension Isoelectric Focusing (IEF) Unit and the SE900 Second-dimension Gel Electrophoresis Unit. The IEF100 helps researchers increase the quality and speed of their IEF separations. The SE900's single-tank design ensures leak-free runs and the ability to reuse buffer. The IEF100's integrated 12,000-volt power supply enables fast run times and provides both ethernet and RS232 ports for reporting and control. The first dimension IEF can be run with IPG (immobilized pH gradient) strips of any length up to 24 cm. Up to six IPG strips can be focused at one time and monitored individually. The IEF100 generates first-dimension separations, then the focused strips are transferred to an SE900 second-dimension slab gel for the second dimension separation by molecular weight. The separation tank can hold up to six second-dimension gels.


For information 800-227-4750

Handheld FTIR Spectrometer

A new handheld, portable Fourier transform infrared (FTIR) spectrometer weighs only six pounds. This innovative analyzer can be operated using only one hand and is capable of handling attenuated transmission reflectance (ATR) applications for users in the general laboratory. Designed for sampling almost any material, the system features interchangeable internal reflectance and external reflectance sampling interfaces. Designed to analyze solids, pastes, gels, and liquids with a traditional ATR, it is also capable of analyzing large surfaces with a unique internal reflection sampling system. It combines all the capabilities of a laboratory-based FTIR with the advantages of a portable instrument.

A2 Technologies

For information 203-312-1106

Metabolite Identification Software

MetWorks 1.1.0 is an updated version of metabolite identification software. The software facilitates automated acquisition, processing, and reporting of liquid chromatography/mass spectrometry (LC/MS) data in support of biotransformation studies. MetWorks software is compatible with all Thermo Scientific mass spectrometers capable of performing MS/MS and MSn fragmentation. It also allows high-resolution mass data from the Thermo Scientific LTQ Orbitrap and LTQ FT instruments to be fully leveraged. The new program's enhanced tools facilitate distinguishing xenobiotic components from endogenous biological matrix interferences in LC/MSn chromatograms and spectra. Improvements to the software include automatic generation of a data-dependent parent mass table and component filtering to exclude duplicates originating from adducts and isotopic contributions. Another improvement is the flexibility to apply up to six multiple mass defect filters, which are based on high-resolution, exact mass, and mass deficiencies of the parent drug and its putative metabolites. Chromatograms and spectra filtered with them contain fewer endogenous compounds and excipient materials, which reduces the need for manual intervention to eliminate false positives from the results.

Thermo Fisher

For information 408-965-6022

Proteomics Mass Spectrometry

With the addition of Compass 1.3 ion trap software, the high-capacity trap HCTultra PTM Discovery System is the first commercial mass spectrometer equipped with electron transfer dissociation (ETD) and proton transfer reaction (PTR) capabilities. The instrument features a unique and innovative ion optics design and chemistry setup for ETD/PTR that allows rapid, routine top-down characterization of large peptides and mid-size proteins in the high-capacity ion trap with superior sensitivity. The usefulness of ETD/PTR is demonstrated by the unambiguous characterization of posttranslational modifica-tions. Compass 1.3 also introduces a novel collision-induced dissociation (CID) fragmentation mode that eliminates the low mass cut-off of ion traps in MS/MS. It enables multiplexed quantitative proteome analyses on Bruker's high-capacity ion-trap systems. A new AutoMSn mode in Compass 1.3 automatically eliminates the most abundant ions in order to further enhance dynamic range.

Bruker Daltonics

For information 978-667-9580

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Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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