Cell Biology

Doing Double Duty

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Science  07 Mar 2008:
Vol. 319, Issue 5868, pp. 1311
DOI: 10.1126/science.319.5868.1311b

During cell division, centrosomes are important in the organization and maintenance of the mitotic spindle. Fielding et al. found that a kinase, integrin-linked kinase (ILK), known to be important in cell adhesion, also interacts with centrosomal and spindle proteins, including the main constituent of the mitotic spindle, tubulin. When ILK was inhibited, cells failed to assemble mitotic spindles properly, resulting in aberrant chromosome segregation. The centrosomal protein RUVBL1 was important for ILK targeting to the centrosome, and the activity of ILK was important for another centrosomal protein, ch-TOG, to promote spindle pole organization and mitosis. This unanticipated role for ILK in promoting centrosomal organization, spindle assembly, and chromosome segregation may represent an important link between cell adhesion and mitosis. — SMH

J. Cell Biol. 180, 681 (2008).

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