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Science  14 Mar 2008:
Vol. 319, Issue 5869, pp. 1547
DOI: 10.1126/science.319.5869.1547

Biological Sample Concentration

The miVac Quattro is a versatile, high capacity biological sample concentrator that rapidly removes a wide range of solvents, from volatile organic solvents to water. It is suitable for use in applications including oligonucleotide synthesis, RNA and DNA preparation, peptide preparation, sequencing, molecular biology, and absorption, distribution, metabolism, excretion, toxicity (ADMET) research. A high displacement pump removes water quickly and quietly. Solvent removal can be enhanced by the addition of a miVac SpeedTrap refrigerated condenser. The four-swing position rotor can simultaneously accommodate up to 20 shallow-well microplates or eight deep-well plates. A wide variety of rotors is available to accommodate formats including tubes, microplates, and vials. The instrument offers digital control of concentrator temperature and short concentration times, reducing the risk of heat damage to samples.


For information 44 1473 240000

Instrument-Free DNA Detection

The BioHelix Express Strip Cassette is a novel, disposable DNA detection device. It is designed for instrument-free, cross-contamination-proof detection of amplicons derived from polymerase chain reaction, helicase-dependent amplification, and other nucleic amplification reactions. The amplicons are dual-labeled by biotin and fluorescein isothiocyanate during amplification and detected on a test strip embedded in the device. The method is 10 times more sensitive than gel-based detection methods, with results viewable as colored lines in 10 minutes.


For information 866-800-5458

Protein-DNA Binding Assay

The Protein-DNA Binding Assay provides a safe, fast, and sensitive alternative to traditional electromobility shift assays for detection and quantitative characterization of protein-DNA interactions. This assay eliminates the need for radioactive labeling and gel electrophoresis because it features chemiluminescent ProLabel detection and can be performed in a 96-well plate. A small (about 6 kDa) ProLabel tag is fused to the protein of interest to generate a fusion protein that is capable of producing a strong chemiluminescent signal via an enzyme complementation assay. The ProLabel tag allows direct detection of specific binding between the protein of interest and a biotinylated double-stranded-DNA oligonucleotide. The biotin moiety on the oligonucleotide permits the resulting protein-DNA complex to be captured on the 96-well plate, which is coated with streptavidin.

Clontech Laboratories

For information 800-662-2566

Bioinformatics Software

ProteinScape 2 software is a next-generation bioinformatics platform designed for addressing needs in biomarker profiling, quantification, and validation. A comprehensive solution for qualitative and quantitative liquid chromatography/mass spectrometry (LC/MS) protein analysis, ProteinScape 2 supports all current label chemistries, including multiplexed labels, as well as label-free quantification. Interactive validation of protein quantification based on raw LC/MS data is simple and straightforward. It streamlines the discovery process through decoy autovalidation algorithms and the ProteinExtractor algorithm, which produces nonredundant protein result lists across entire proteomics projects. The software has a number of dedicated data viewers that permit the evaluation and validation on each level of proteomics experiments, such as the LC/MS survey viewer, the gel viewer, and sequence MS/MS spectra. All these views are linked and permit simple browsing through scientists' proteomics data, supported by extensive queries.

Bruker Daltonics

For information 978-667-9580

Orange Fluorescent Label

The Qdot 625 nanocrystal fluorescent label can be seen as orange and fills an important spectral gap for dense multicolor experiments. In addition, the Qdot 625 glows more brightly than longer wavelength Qdots. Current products using it include the Qdot 625 streptavidin conjugate, the Qdot 625 goat F(ab')2 antimouse IgG conjugate, and the Qdot 625 F(ab')2 antirabbit IgG conjugate. When excited by a single light source, Qdot nanocrystals emit in a range of brilliant, articulate colors with long-term photostability.


For information 800-955-6288

Biodiesel Gas Chromatography

The Thermo Scientific Biodiesel Gas Chromatography (GC) Productivity Solutions provide a high level of integration and productivity for the three most common GC-based methods: EN 14103 for Fatty Acid Methyl Ester characterization and linolenic acid methyl ester determination, EN 14105/ASTM D6584 for free and total glycerine content, and EN 14110 for methanol content. Delivering complete automatic characterization of pure biodiesel, the systems offer full compliance with these official standards, which aim to certify the quality of pure biodiesel for any commercial trading. The interest in biodiesel as a clean-burning alternative fuel produced from renewable sources has increased tremendously over the past few years because of its environmental advantages over conventional petrodiesel.

Thermo Fisher

For information 408-965-6022

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Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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