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Researchers Hone Their Homology Tools

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Science  21 Mar 2008:
Vol. 319, Issue 5870, pp. 1612
DOI: 10.1126/science.319.5870.1612

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How well do homology models, which use solved structures as templates for computer models of the three-dimensional shapes of closely related proteins, work? Not well enough, according to members of a review panel that issued a mixed report card on the Protein Structure Initiative in December.