Cell Biology

Activity at the Pore

See allHide authors and affiliations

Science  28 Mar 2008:
Vol. 319, Issue 5871, pp. 1737
DOI: 10.1126/science.319.5871.1737b

Throughout the nucleus, chromosomal regions localize to particular subcompartments, such as the nuclear periphery, that correspond with gene activation or repression. For example, genes positioned near the lamin-rich regions of the nuclear envelope in Drosophila generally correlate with transcription repression. Relatively less is known about spatial regulation in mammalian cells. Brown et al. have used biochemical mapping and visualization techniques in human cells to elucidate genomic organization at the nuclear pore complex. Upon treatment with a histone deacetylase inhibitor, extensive nuclear reorganization resulted, with an increased association of the nuclear pore protein nucleoporin 93 with genomic features and transcription factors characteristic of transcriptionally active genes. Hence, the nuclear pore plays an important part in the regulation of genes in the human genome. — BAP

Genes Dev. 22, 627 (2008).

Navigate This Article