Special Perspectives

Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

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Science  28 Mar 2008:
Vol. 319, Issue 5871, pp. 1791-1792
DOI: 10.1126/science.1150843

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Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.

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