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Science  11 Apr 2008:
Vol. 320, Issue 5873, pp. 250
DOI: 10.1126/science.320.5873.250

High Throughput DNA/RNA Purification

The Clarity QSP system for synthetic RNA and DNA purification delivers nearly impurity-free, concentrated, full-length oligonucleotide sequences. Clarity QSP is offered in three cartridge formats and in 96-well plates. The cartridge formats are suitable for applications that require increased loading capacities, and can purify oligonucleotide samples in less than eight minutes using vacuum or positive pressure systems. The 96-well plate format can be easily automated for high throughput parallel purification and eliminates the tube-in-plate combination of other approaches. Clarity QSP overcomes the pitfalls of first generation trityl-on purification. The system's unique buffer works synergistically with ammonia-based deprotecting solutions to selectively retain the full-length trityl-on DNA or RNA sequence. The method eliminates subsequent wash steps and does not require toxic ion-pairing reagents. It delivers DNA at 90 percent to 95 percent purity, with recovery rates of more than 80 percent and RNA at 89 percent to 93 percent purity, with recovery rates of more than 75 percent.


For information 310-212-0555

cDNA Synthesis Kit

The SuperScript VILO cDNA Synthesis Kit, the latest in a family of reverse transcription kits, provides reliable and sensitive first-strand complementary DNA (cDNA). The kit features RNase-H‐reduced SuperScript III Reverse Transcriptase, which generates increased yields of cDNA and improves quantitative polymerase chain reaction (qPCR) sensitivity up to fourfold over similar systems, according to the manufacturer. In addition, the new kit allows linear detection in a downstream qPCR reaction from as little as 1 picogram of starting RNA up to 2.5 micrograms in a 20-microliter reaction. The kit makes use of an enhanced reaction mix that includes a helper protein designed for minimizing qPCR inhibition, leading to improved detection.


For information 800-955-6288

Single Nucleotide Polymorphism Chips

The new Infinium HD BeadChip product line for DNA analysis features up to 2.3 million single nucleotide polymorphisms (SNPs) per BeadChip. The Human 1M-Duo BeadChip offers two samples per chip, and the Human610-Quad BeadChip offers four samples per chip. Both feature enhanced signal discrimination and a new SNP calling algorithm. The new BeadChips offer significant advances over previous products, including increased sample throughput, lower input sample volume, and improvements to the Infinium assay that enhance system performance. Both arrays on the Human 1M-Duo BeadChip contain markers for more than 1 million diverse genetic variants, all of which can be used for both whole-genome genotyping and copy number variation analysis. It includes recently identified disease-associated SNPs and intelligently selected high-density SNPs in coding regions of the genome. Built on the content of Illumina's broadly adopted HumanHap550 BeadChip, the Human610-Quad BeadChip has 550,000 SNPs plus an additional 60,000 genetic markers per sample.


For information 800-809-4566

Proteasome Inhibitors

The proteasome is a large barrel-like protein in the cytoplasm and nucleus of eukaryotic cells. The main function of the proteasome is to degrade unneeded and damaged proteins by proteolysis. The proteasomal degradation pathway is involved in many cellular processes including the cell cycle, gene expression, and responses to oxidative stress. A variety of proteasome inhibitors are available for research in these areas.

Tocris Bioscience

For information 800-421-3701

Monoclonal Antibody

Human glypican 3 (GPC3) is an oncofetal tumor antigen involved in growth regulation, cell division, and migration. The GPC3 Monoclonal Antibody (clone 1G12) can detect GPC3 in tissue by immunohistochemistry. Suitable for use on formalin-fixed, paraffin-embedded tissue sections, it is available in prediluted and concentrated form for manual use or in automated instruments.


For information 802-656-5443

Spill Detector

The OS*250 system detects spills and leaks before they can cause a problem in an expensive microscope or other piece of equipment. As little as three drops of liquid cause the OS*250 to react. The system consists of a control unit and moisture sensing mat made from a material specially developed for detecting spills. It is connected to the control unit by a simple connection cable. When liquid is detected on the sensing mat, the controller sounds an audible alarm, flashes an LED, and turns off the power of any device plugged into the single outlet, solid-state power controller. The spill sensor is supplied with the controller and four reusable 30 cm by 30 cm mats that can be cut to any size.

KD Scientific

For information 508-429-6809

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Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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