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Science  16 May 2008:
Vol. 320, Issue 5878, pp. 954
DOI: 10.1126/science.320.5878.954

High Throughput Transfection System

The VirTis 96 Well Freeze Drying System for high throughput applications combines a choice of glass or plastic vials, set in an aluminum vial holder. The solid aluminum 96-well vial holders provide efficient and even heat distribution to ensure fast and consistent freeze-drying results for every sample. A range of glass-vial sizes is available. The new fluted LyoCap 96 Well CapMat Stoppers enable samples to be quickly freeze-dried and then sealed under vacuum, inert gas, or filtered air after the lyophilization cycle is complete. In traditional 96-well freeze-drying systems, samples in the wells around the plate edges tend to dry more quickly, but the VirTis sytem eliminates this effect. The system's effectiveness means scientists have an alternative to storing sensitive or heat-labile samples at low temperatures.

Genevac

For example +44-1473-240000

http://www.genevac.com/

Yeast RNA Purification

The MasterPure Yeast RNA Purification Kit provides all the reagents needed to purify RNA from various yeast cell types, including Candida, Saccharomyces, Schizosaccharomyces, and from filamentous fungi, such as Aspergillus. The kit makes use of a rapid desalting process to remove contaminating macromolecules, avoiding toxic organic solvents, bead beating, and spheroplasting. The resulting MasterPure RNA is of higher quality than that obtained from bead-beating and is suitable for gene expression analysis.

Epicentre Biotechnologies

For information 800-284-8474

http://www.epibio.com/

Basement Membrane Extract

The PathClear Basement Membrane Extract (BME) can be used for promotion and maintenance of a differentiated phenotype in a variety of cell cultures, including primary epithelial cells, endothelial cells, and smooth muscle cells. It has been used in angiogenesis assays, in tumor cell invasion assays, and as a vehicle to augment the tumorgenicity of tumor cells injected in nude mice. The PathClear designation means that in addition to standard sterility, endotoxin, and mouse antibody production testing, the BME is tested by polymerase chain reaction and is clear of a battery of 31 pathogens. Each lot is rigorously qualified in biological performance assays. Available in reduced growth factor form, with and without phenol red, PathClear BME is expected to be of special interest for in vivo murine research and other work requiring BME free from viruses, bacteria, and mycoplasma.

Trevigen

For information 800-873-8443

http://www.trevigen.com/

Low Volume Absorbance Applications

The Infinite 200 NanoQuant is a multimode microplate reader developed for absorbance applications with low volumes. It is available with Tecan's quad4 monochromators, which provide high wavelength accuracy for endpoint measurements over the entire spectral range. It is also available with new 260 nm or 280 nm filters with an ultraviolet-stable coating that provide exact central wavelengths and narrower bandwidths. It can detect DNA concentrations as low as 1 ng/μl. It is suitable for a broad range of applications, including DNA and RNA quantitation and quality control. It offers sensitivity, multiplexing capability, and format flexibility from 6-well to 384-well microplates as well as half-area plates and the new NanoQuant plate for low concentration and sample volumes. The new NanoQuant plate contains a special quartz optic for each of the 16 samples it holds. It offers quick and easy cleaning to reduce the risk of cross contamination. The NanoQuant can be upgraded with additional detection modes.

Tecan

For information +41 44 922 81 11

http://www.tecan.com/

Multifrequency Fluorometer

The MF2 (Multi-Frequency Fluorometer) performs faster fluores-cence lifetime measurements, providing previously unattainable insight into the molecular behavior of cells, nanodevices, and other research materials. By grouping multiple frequencies into one high frequency waveform and greatly expanding the available frequency range, the instrument decreases the time it takes to measure a fluorescence lifetime from minutes to milliseconds, a 10,000-fold change.

Horiba Jobin Yvon

For information 800-446-7422

http://www.horiba.com/

Filter Plates

An addition to the MultiScreen family, the MultiScreenHTS+ filter plates are for radiometric kinase and G protein-coupled receptor assays. These filter plates have a mesh backing to create uniformly flowing wells to improve washing efficiency. The new plate design reduces overall nonspecific binding and reduces variability in both background and signal intensities. The filter plates allow for higher throughput, greater assay sensitivity, and detection flexibility.

Millipore

For information 800-548-7853

http://www.millipore.com/

Rodent Respiration Monitoring

The Oxylet System is designed for monitoring respiratory metabolism in rodents. Through use of an indirect calorimetry system, the Oxylet monitors carbon dioxide production, oxygen consumption, and respiratory ratio. It can be scaled up to monitor 32 animals simultaneously. Each animal chamber has an independent flow meter, so one system can accommodate multiple species at the same time. It is suitable for studies of obesity, diabetes, athletic exercise training, and other respiratory-challenging conditions.

Harvard Apparatus

For information 800-272-2775

http://www.harvardapparatus.com/

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Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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