Technical Comments

Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"

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Science  23 May 2008:
Vol. 320, Issue 5879, pp. 1012
DOI: 10.1126/science.1152366

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Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

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