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Response to Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"

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Science  23 May 2008:
Vol. 320, Issue 5879, pp. 1012
DOI: 10.1126/science.1152620

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Differences in reported life span of mice heterozygous for a null allele of the insulin receptor substrate–2 (Irs2) might involve the effects of diet, breeding strategies, and genetic background on insulin-like signaling cascades. A better understanding will emerge from studies focusing on the coordination of nutrient homeostasis and life span by insulin-like signaling in specific peripheral tissues and the central nervous system.

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