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Transfer of Learning After Updating Training Mediated by the Striatum

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Science  13 Jun 2008:
Vol. 320, Issue 5882, pp. 1510-1512
DOI: 10.1126/science.1155466

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  1. Fig. 1.

    (A) Letter memory and 3-back performance for training and control groups. The histograms denote mean effect sizes. (B) Training gains in younger and older adults during the 5-week intervention period. Error bars indicate SEM. Asterisks indicate statistical significance; n.s., not significant.

  2. Fig. 2.

    (A) Brain maps to the left (dorsal view) show activation of bilateral parietal cortex and lateral and medial frontal cortex for all tasks at pretraining. Conjunction analyses of the letter memory (LM) task with Stroop and 3-back revealed overlapping frontoparietal activation patterns for the criterion task and both transfer tasks (cortical maps to the right). The bar graph (bottom) shows the striatal activation profile across tasks at pretraining and reveal overlapping activations in LM and 3-back (plotted at peak x = –20, y = 4, and z = 14). (B) Brain map to the left shows activation of bilateral parietal cortex and lateral and medial frontal cortex for LM pretraining. The bar graph shows no significant striatal activation in LM for older adults (plotted at peak x = –24, y = 10, and z = –2, where selective training-related increases were found). Error bars indicate SEM.

  3. Fig. 3.

    (A) Left striatum (peak x = –20, y = 4, and z = 14) was activated before training and showed a training-related increase for both letter memory and 3-back in younger adults. The bar graph shows the activation profiles across tasks and sessions. The red line indicates mean baseline bold values for the striatal region (mean of trained before, controls before, and controls after). (B) Left striatum (peak x = –24, y = 10, and z = –2) showed a training-related increase for letter memory in older adults. Error bars indicate SEM.