Report

Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors

+ See all authors and affiliations

Science  20 Jun 2008:
Vol. 320, Issue 5883, pp. 1651-1654
DOI: 10.1126/science.1158160

You are currently viewing the abstract.

View Full Text

Abstract

Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. The L. pneumophila AnkX protein prevented microtubule-dependent vesicular transport to interfere with fusion of the L. pneumophila-containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells.

    View Full Text