News of the WeekVirology

'Biased' Viruses Suggest New Vaccine Strategy for Polio and Other Diseases

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Science  27 Jun 2008:
Vol. 320, Issue 5884, pp. 1709
DOI: 10.1126/science.320.5884.1709a

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Introducing hundreds of seemingly inconsequential mutations into a poliovirus can cripple the virus enough to make it work as a live vaccine in mice, scientists report on page 1784 of this week's issue of Science. The technology might lead to safer polio vaccines and perhaps to so-called live attenuated vaccines against other diseases.