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Response to Comment on "Genetically Determined Differences in Learning from Errors"

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Science  11 Jul 2008:
Vol. 321, Issue 5886, pp. 200
DOI: 10.1126/science.1156079

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Since the publication of our findings, further genetic and pharmacological studies have bolstered our conclusion that dopamine D2 receptors are essential for performance monitoring and learning. Although the functionally complex dopamine D2 receptor gene polymorphism DRD2-TAQ-IA may also affect cellular signaling components, the accumulated evidence supports the notion that our findings were mediated by differential D2 receptor density.

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