X Inactivation Is a Good Thing

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Science  11 Jul 2008:
Vol. 321, Issue 5886, pp. 202-203
DOI: 10.1126/science.1154430

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Females Are Mosaics. X Inactivation and Sex Differences in Disease. By Barbara R. Migeon. Oxford University Press, Oxford, 2007. 291 pp. $59.95, £35.99. ISBN 9780195188127.

Discussing the medical consequences of X inactivation and effects on individuals with chromosome abnormalities the author molecular mechanisms for chromosome inactivation and addresses the evolutionary origins of human sex chromosomes.