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Response to Comment on "A 3-Hydroxypropionate/4-Hydroxybutyrate Autotrophic Carbon Dioxide Assimilation Pathway in Archaea"

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Science  18 Jul 2008:
Vol. 321, Issue 5887, pp. 342
DOI: 10.1126/science.1158879

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We proposed that the 3-hydroxypropionate/4-hydroxybutyrate cycle might be important in global carbon cycling based on the abundance of related autotrophic Crenarchaea in the ocean and the high number of gene sequences for a key enzyme of the cycle. Here, we counter the specific criticisms raised by Ettema and Andersson.

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