Special Perspectives

Outwitting Multidrug Resistance to Antifungals

+ See all authors and affiliations

Science  18 Jul 2008:
Vol. 321, Issue 5887, pp. 367-369
DOI: 10.1126/science.1159746

You are currently viewing the abstract.

View Full Text


The economic cost of fungal infection and its mortality associated with multidrug resistance remain unacceptably high. Recent understanding of the transcriptional regulation of plasma membrane efflux pumps of modest specificity provides new avenues for the development of broad-spectrum fungicides. Together with improved diagnosis and indirect intervention via inhibition of the energy supply for drug efflux, we envisage multifunctional azole analogs that inhibit not only ergosterol biosynthesis and drug efflux-pump activity but also activation of the transcriptional machinery that induces drug efflux-pump expression.

View Full Text