Development

Pore Differentiation

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Science  01 Aug 2008:
Vol. 321, Issue 5889, pp. 613
DOI: 10.1126/science.321.5889.613b

Developmental signals are relayed inside cells via nucleocytoplasmic transport in which information and macromolecules are exchanged between the cytoplasm and nucleus via the nuclear pore complex (NPC), which in mice is composed of about 30 different proteins. Thus far, mutational analyses of several nucleoporins have produced embryonic lethality. Lupu et al. find that mouse embryos express the conserved nucleoporin Nup133 in a cell-type- and stage-specific pattern, suggesting that it may not function as a general structural component of the NPC but could instead be a modulator of NPC activity. When Nup133 was disrupted, nuclear pore complexes assembled normally, but mouse gastrulation was defective. Specifically, neural progenitors formed, but cells maintained the features of an earlier pluripotent state and differentiated inefficiently. — BAP

Dev. Cell 14, 831 (2008).

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