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Science  05 Sep 2008:
Vol. 321, Issue 5894, pp. 1374
DOI: 10.1126/science.321.5894.1374a

LC-MS/MS System

The TSQ Vantage is a new liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) system that offers increased sensitivity without increased noise for better reproducibility, accuracy, and precision in quantitative analysis. Technical breakthroughs have improved the TSQ Vantage's signal-to-noise performance, providing better reproducibility and precision in the quantitative analysis of small molecules, biomolecules, and peptides. The instrument offers up to 10 times the signal-to-noise ratio compared with the TSQ Quantum series. The TSQ Vantage's new S-Lens ion optics system features a novel electrostatic field technology to capture virtually every ion and efficiently transfer it into the HyperQuad quadrupole mass analyzer. The S-Lens design is an advance over high-pressure, skimmer-based ion source designs because it eliminates mass discrimination and lowers the gas load on the expensive turbo-molecular pumps.

Thermo Fisher Scientific

For information 800-532-4752

Glycopeptide Analysis Software

The new version of the innovative mass spectrometry (MS) data analysis tool, SimGlycan, can analyze glycopeptides in addition to released glycans. SimGlycan matches MS/MS spectra with its own comprehensive, robust, and annotated database to predict the structure of glycans. It generates a list of all the probable glycans that are close to the experimental data, saving time and laborious work. Each structure is scored to help the user judge which results closely match the experimental data. Alongside the probable glycan structure, the software makes available information such as the glycan class, reaction, pathway, and enzyme. Users can resolve glycan structures in glycopeptide molecules by specifying the sequence or mass of the attached peptide moiety.

Premier Biosoft International

For information 650-856-2703


ProteasMAX Surfactant is designed to enhance the enzymatic performance of trypsin and other proteases in preparation for analysis by mass spectrometry or liquid chromatography. The surfactant provides a more complete digestion prior to protein analysis, resulting in more accurate data in a shorter time and reduced risk of sample degradation. The new surfactant exposes cleavage sites usually inaccessible because of secondary or tertiary structure and can increase sample recovery from gels. It can reduce standard protein digestion time from overnight to just three hours. It also enhances protein solubilization at room temperature, which means that high temperatures and precipitation can be avoided, even for complex proteins. Because ProteasMAX degrades during the digestion reaction, researchers can proceed directly to analysis of peptides by mass spectrometry without additional deactivation steps.


For information 608-274-4330

Cell Lysis Kit

The ProteaPrep Cell Lysis Kit, Mass Spec Grade, is designed for the efficient recovery of purified protein lysates from biological samples. The kit is a proprietary mixture of salts, glycerol, and an acid-labile surfactant optimized for efficient solubilization, extraction, and recovery of proteins during cell lysis. Because the kit contains no lysozyme or harsh detergents, it permits recovery of cell lysates free from artifactual protein contaminants and promotes efficient sample protein solubilization. It is optimal for mass spectrometry, enzymatic digestions, two-dimensional gel electrophoresis, and protein quantitation procedures.

Protea Biosciences

For information 877-776-8321

Tandem Quadrupole MS

The Waters Xevo TQ MS System is an advanced tandem quadrupole mass spectrometer that allows scientists with varying levels of mass spectrometry (MS) expertise to quickly produce high quality data. The system features IntelliStart, a new technology that simplifies instrument setup and troubleshooting. It automatically ensures the system is ready for use by performing mass calibration, setting MS resolution, generating compound-specific MS methods, and optimizing source conditions. The instrument is equipped with a unique collision cell that can be operated in conventional T-Wave-1 enabled mode or in a new ScanWave-enabled mode. ScanWave improves the duty cycle and enhances the full-scan capability to meet the demands of complex analyses, allowing users to more easily confirm the identities and structures of targeted analytes.


For information 508-482-2614

High-Resolution Time-of-Flight MS

The maXis electrospray ultrahigh-resolution time-of-flight mass spectrometer offers high resolution of 40,000–60,000 FWHM over a broad mass range and mass accuracy typically between 600 and 800 parts per billion, at speeds of up to 20 full spectra per second. The maXis offers 20 Hz full spectra acquisition at high mass resolution for high-speed liquid chromatography, a high dynamic range of five orders of magnitude for trace detection in complex mixtures, and sub-parts-per-million mass accuracy in both mass spectrometry (MS) and MS/MS mode. The instrument makes high-resolution mass spectrometry over a broad mass range compatible with ultra performance liquid chromatography.

Bruker Daltonics

For information 978-667-9580

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