10 October 2008
Vol 322, Issue 5899
  • Contents

    • This Week in Science

    • Editorial

    • Editors' Choice

    • Departments

    • Multimedia

    • Podcasts

      • Science Podcast

        The 10 October 2008 show includes digital blueprints of vertebrate development, a single-species ecosystem deep within the Earth, clinical trials gridlock, and more.

    • Products & Materials

    • News of the Week

      • HIV, HPV Researchers Honored, But One Scientist Is Left Out

        The 2008 Nobel Prize in physiology or medicine has been awarded to Luc Montagnier and Françoise Barré-Sinoussi for their discovery of the virus that causes AIDS--but not Robert Gallo, whom many consider to have co-discovered the virus with Montagnier. A third prize went to German virologist Harald zur Hausen for finding that human papillomaviruses can cause cervical cancer.

      • Pacific Northwest Sea Bird May Lose 'Threatened' Status

        The U.S. Fish and Wildlife Service agreed last week to review the protected status of the marbled murrelet, a sea bird that nests in the coastal forests of the Pacific Northwest, in response to a timber-industry-led petition claiming that the bird does not meet key provisions of the Endangered Species Act.

      • Comprehensive Conservation Database Details Threats to Mammals

        Earlier this week, the International Union for Conservation of Nature released a database detailing the status of all mammals known to humankind since the year 1500. On page 225 of this week's issue of Science, the team that assembled the database analyzes the findings. The news is bleak, particularly for the oceangoers.

      • Do Voter Surveys Underestimate the Impact of Racial Bias?

        Some social scientists think that many voters who say they support Democratic candidate Senator Barack Obama in fact may be uncomfortable with the prospect of an African-American president or that polls have failed to reach Democratic voters most likely to harbor such prejudice, and that some fraction of those people may vote for Republican Senator John McCain--or not vote at all.

    • News

      • Spiraling Costs Threaten Gridlock

        The gold standard of medical science--the big randomized trial--is in danger of being priced out of reach by technical complexity, poor management, and paperwork.

      • Allegations of Waste: The 'Seeding' Study

        Internal company documents suggesting that a 1999 trial of the Merck painkiller Vioxx had more to do with marketing than with science have focused new attention on so-called seeding trials aimed at promoting new treatments.

      • Women Abound in NIH Trials

        A campaign that began in the 1990s to include more female participants in clinical trials funded by the U.S. National Institutes of Health may have been more successful than people realize.

      • Cholesterol Veers Off Script

        Recent trials of drugs that either lower "bad" cholesterol or raise the "good" kind have produced surprising results; along with genetics research, these findings have put in question some long-held beliefs.

    • ScienceScope

    • Random Samples

    • Newsmakers

    • News Focus

    • The Gonzo Scientist

      • Calling All Dancing Scientists!

        If you missed this year's "Dance Your Ph.D." contest, act fast: The deadline to enter the 2009 contest, for which the stage will be much larger and the prize far grander, is 16 November 2008.

    • Letters

    • Books

    • Policy Forum

    • Perspectives

      • Sauropod Gigantism

        How did sauropod dinosaurs reach body sizes that remain unsurpassed in land-living animals?

      • Regulating Suppression

        How a T cell protein suppresses the immune response will help guide the development of therapies that do not have autoimmune side effects.

      • Armor Development and Fitness

        The fitness of stickleback fish that develop different numbers of external bony plates varies between oceanic and freshwater environments.

      • Volcanic Symphony in the Lab

        Analysis of acoustic signals from lab samples links rapid pressure drops of pore fluids with low-frequency volcanic earthquakes.

    • Introduction to special issue

    • Brevia

      • Collective Behavior in an Early Cambrian Arthropod

        Fossil arthropods in 525-million-year-old rocks in China are preserved in a long chain, implying that some Cambrian animals exhibited social behavior, unlike later arthropods.

    • Research Articles

      • The Status of the World's Land and Marine Mammals: Diversity, Threat, and Knowledge

        A comprehensive assessment of all of Earth's mammals shows that primary productivity drives species richness on land and sea and that 20 to 25 percent of species are under threat.

      • A High Phase-Space-Density Gas of Polar Molecules

        Raman laser irradiation can cool a cloud of KRb molecules to ultralow translational, vibrational, and rotational temperatures, a step toward forming molecular condensates.

    • Reports

    • From the AAAS Office of Publishing and Member Services

About The Cover

Cover image expansion

COVER Steep terrain: To move a therapy from the research lab to the doctor's office requires a huge investment in clinical trials, which are growing more costly and more complex every year. See the special section beginning on page 209. Photo illustration: Kelly Buckheit Krause (images: Getty Images; Jupiter Images)