Special Reviews

Feedback Loops Shape Cellular Signals in Space and Time

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Science  17 Oct 2008:
Vol. 322, Issue 5900, pp. 390-395
DOI: 10.1126/science.1160617

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Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.

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