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Paul Klee, a Tragic Metamorphosis

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Science  31 Oct 2008:
Vol. 322, Issue 5902, pp. 669
DOI: 10.1126/science.322.5902.669

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Summary

Art experts believe scleroderma had a major impact on modern artist Paul Klee, as his later works shifted from vibrant to darker colors and emphasized themes such as mortality and suffering.