Technical Comments

Response to Comment on "Differential Rescue of Light- and Food-Entrainable Circadian Rhythms"

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Science  31 Oct 2008:
Vol. 322, Issue 5902, pp. 675
DOI: 10.1126/science.1161387

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The points raised by Mistlberger et al. arise from a shortcoming in their approach, namely, that they measure the response to food restriction by using food-seeking behavior, which is confounded by homeostatic inputs. We used unrelated circadian-driven physiological responses, and we stand by our finding that the dorsomedial nucleus of the hypothalamus contains a food-entrainable oscillator that is sufficient for entrainment of circadian rhythms of body temperature and locomotor activity.

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