Review

Genetic Mapping in Human Disease

Science  07 Nov 2008:
Vol. 322, Issue 5903, pp. 881-888
DOI: 10.1126/science.1156409

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Abstract

Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.

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