Mouse Genome Bonanza

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Science  19 Dec 2008:
Vol. 322, Issue 5909, pp. 1777
DOI: 10.1126/science.322.5909.1777d

A $4.4 million project to sequence the DNA of 17 strains of mice will make these animals more useful for tracking down genes and assessing genetic risks for human diseases. Over the next 3 years, the Wellcome Trust Sanger Institute in Hinxton, U.K., will generate up to 3 trillion bases of mouse DNA, using new low-cost and high-speed sequencing methods, to compile fairly complete genomes of the most commonly used mouse strains. Those strains include those used to make knockout mice, the parent strains for lines used in studies of diseases such as diabetes, obesity, and asthma, and eight strains that are the starting points for the development of 1000 new inbred lines. Partners include the U.K. Medical Research Council, the Juvenile Diabetes Research Foundation, the Wellcome Trust and MRC genetics labs, the European Bioinformatics Institute, and the Jackson Laboratory.

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