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Science  19 Dec 2008:
Vol. 322, Issue 5909, pp. 1869
DOI: 10.1126/science.322.5909.1869a

Multiplex Data Software

Milliplex Analyst is original equipment manufacturer's software that is seamlessly integrated with Luminex xPonent software, the system that controls Luminex multiplexed bioassay instruments. Multiplexing is virtually universal in the drug discovery industry and the Luminex system is one of the most commonly used platforms. Milliplex Analyst allows users to analyze multiplex data with accuracy, speed, and efficiency. Data sets can be easily extracted from acquisition or imported as Excel or text files. The software's unique algorithms and analytics allow robust processing of challenging data sets in seconds, with multiple output format options for maximum flexibility. Multiplate data can be analyzed using a variety of curve-fitting options to generate reports that feature fitting parameters and statistics.

Millipore and VigeneTech

For information 800-548-7853

http://www.millipore.com/

Digital Imaging System

The AlphaImager Mini is a compact and economical digital imaging system suitable for routine imaging of fluorescent and colorimetric DNA and protein gels. The Mini's scientific-grade, 1.3-megapixel camera acquires high-resolution images suitable for quantitative downstream analysis. Images are captured using streamlined software, then can be printed directly to any digital or Windows-compatible printer and saved in several standard file formats. The instrument's cabinet offers a large pull-door for sample access and an ultraviolet-shielded viewport in a footprint less than 11 inches by 14 inches. It is compatible with ethidium bromide, SYBR green, Coomassie, silver stain, and more.

Alpha Innotech

For information 510-904-5647

http://www.alphainnotech.com/

Low-Pressure Chromatography Columns

AxiChrom columns for low-pressure chromatography are designed to support the lean-enabling approach to column operation and maintenance. The columns feature “Intelligent Packing,” in which preprogrammed and verified packing methods save time and make packing less dependent on the operator. The columns have a novel design with a pivot or swing-out column tube that provides easy access for maintenance. They are easy to prime, operate, and service with interactive guidance from the AxiChrom Master and Unicorn method wizard. AxiChrom columns are available with diameters from 50 mm to 1,000 mm, allowing users to choose the most suitable column size for separations from process development to full-scale production. They are designed to enable predictable scale-up for reproducible results over a range of column diameters and lengths.

GE Healthcare

For information +44-(0)20-7457-2020

http://www.gehealthcare.com/

Proteomics Imaging System

The FLA-9000 is a modular image scanner for proteomic applications in radioisotopic, fluorescent, chemiluminescent, and digitized imaging. The FLA-9000 is designed for customized upgradeability and features a 40 cm by 46 cm scanning area. It is suitable for fluorescence detection of two-dimensional gels by SYPRO Ruby stain and digitization of Coomassie-brilliant-blue–stained or silver-stained samples. It can be configured in three different models. The IP Model is apt for storage phosphor imaging and records image data in a log file format for greater linear accuracy when analyzing images containing the large dynamic range information sets that radioisotopes can generate. The RGB Model is for multispectral two-dimensional gel imaging. It allows researchers to complete scans of samples labeled with Cy3 and Cy5 dyes in a single run. The IR+IP Model, for conducting near infrared and radioisotope imaging, accommodates up to four lasers to scan imaging plates as well as quantum dots and traditional fluorophors that emit in near infrared.

Fujifilm Life Science

For information 866-902-3854

http://www.fujifilmlifescienceusa.com/

Membrane Protein Interactions

Designed to detect novel interaction partners for membrane proteins, the DUALmembrane System can be used to detect pairwise protein interactions, identify novel protein interactions by complementary DNA library screening, investigate ternary complexes, and map interaction domains. The system reliably detects interactions between integral membrane proteins and receptor subunits and co-receptors, as well as membrane-associated proteins and soluble proteins. It is based on the properties of ubiquitin, a small protein modifier that is conserved in all eukaryotes and plays a primary role in protein degradation. The system is available in both kit form and as a custom screening service.

Dualsystems Biotech

For information +41-(0)1-738-50-00

http://www.dualsystems.com/

Cell-Free Protein Expression

New additions to the TNT system include an insect system and an improved bacteria system for cell-free expression of proteins. The recent additions expand a comprehensive offering of tools for cell-free expression of proteins from DNA in a single reaction. The insect lysate system delivers expression at a lower temperature than other systems, which can enhance protein folding and stability and is often preferred for mutagenesis studies. The TNT system is a single-step process that makes use of DNA as a template for the coupled transcription/translation, and saves the user from the need to purify and quantify messenger RNA for in vitro expression. Cell-free protein expression's advantages over cell-based protein expression include time savings and increased yields of functional, soluble, full-length proteins.

Promega

For information 608-274-4330

http://www.promega.com/

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Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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