Technical Comments

Response to Comment on "Human-Specific Gain of Function in a Developmental Enhancer"

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Science  06 Feb 2009:
Vol. 323, Issue 5915, pp. 714
DOI: 10.1126/science.1166571

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Duret and Galtier argue that human-specific sequence divergence and gain of function in the HACNS1 enhancer result from deleterious biased gene conversion (BGC) with no contribution from positive selection. We reinforce our previous conclusion by analyzing hypothesized BGC events genomewide and assessing the effect of recombination rates on human-accelerated conserved noncoding sequence ascertainment. We also provide evidence that AT → GC substitution bias can coexist with positive selection.

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