Report

Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training

Science  06 Feb 2009:
Vol. 323, Issue 5915, pp. 800-802
DOI: 10.1126/science.1166102

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.

View Full Text

Cited By...