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Science  20 Feb 2009:
Vol. 323, Issue 5917, pp. 1083
DOI: 10.1126/science.323.5917.1083a

Mass Spectrometer

The AB Sciex Qtrap 5500 System is a next-generation mass spectrometer that combines high sensitivity, scanning speed, and capacity to analyze a greater number of compounds, proteins, and contaminants in a single run than previously possible. The system integrates triple quadrupole capabilities with an innovation in ion trap technology called Linear Accelerator Trap for combined quantitative and qualitative analysis. The system supports multiple experiments on the same instrument through a proprietary innovation, called TripleTrap Scanning, that allows scientists to move from sensitive, specific, triple quadrupole scan modes to highly sensitive full-scan ion trap mode in less than one millisecond.

Applied Biosystems

For information 800-327-3002

SFC Columns

A new line of supercritical fluid chromatography (SFC) columns brings new phases and selectivities to SFC separations, expanding the use of this technology to analytical and preparative applications. SFC offers several advantages over high-performance liquid chromatography, including improved resolution, faster separations, and higher throughput. SFC also reduces the use of toxic solvents. SFC columns have applications in pharmaceutical and academic research as well as medicinal chemistry. Phenomenex's new SFC offerings include the Luna HILIC (hydrophilic interaction liquid chromatography) columns with unique, cross-linked diol chemistry for analysis of polar metabolites; Synergi Polar-RP (ether-linked phenyl phase) for polar and aromatic analysis; and Lux chiral phases.


For information 310-212-0555

Liquid Chromatography System

The AKTAready liquid chromatography system is designed for process scale-up and production for drug development and full-scale production following good laboratory practice and good manu-facturing practice standards. The system can improve cost efficiency and productivity by saving time and expenditures for startup, labor, and consumables. AKTAready operates with ready-to-use, disposable flow paths, eliminating the risk of cross-contamination and the need for cleaning and validation of cleaning procedures. The system includes the chromatography unit, Unicorn software, and a disposable ReadyToProcess Flow Kit including sensors and detection flow cells. The software includes an installation wizard with instructions and reports for column installation. The system is supported by extensive regulatory product documentation and services, including validation documentation, product documentation, and more.

GE Healthcare

For information 800-526-3593

Stain-Free Imaging

The Criterion Stain Free imaging system for detection and quantitation of proteins consists of a new formulation of Bio-Rad's Criterion precast gels, a Criterion Stain Free imager, and Image-Lab software. The new system enables scientists to bypass the staining and destaining steps of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and visualize protein samples in 2.5 minutes after electrophoresis. In addition, the system captures digital images of gels to make record-keeping easy, with no need for a gel drying step. Benefits of the system include one-touch instrument operation, equal or improved sensitivity compared with a Coomassie stain, compatibility with protein immunoblotting and mass spectrometry, and digital images and data that are easy to share, print, and store. There is no organic waste.

Bio-Rad Laboratories

For information 800-424-6723

Antibody Purification Tools

The PureProteome Protein A and Protein G Magnetic Beads enable researchers to perform small-scale purifications faster and more easily. The beads provide high binding capacity for high recovery of protein. The beads also ensure reproducible separation of immunoglobulins (IgG) by allowing for total removal of buffers and complete recovery of beads. Magnetic beads were developed to ensure rapid and reproducible purifications by immobilizing the beads to the side of the tube allowing for total removal of buffers with no loss of sample. In the past, magnetic beads have had significantly lower binding capacities than other bead-based purification media, but PureProteome beads overcome this by binding higher amounts of IgG. PureProteome beads are available with an optional magnetic rack that immobilizes the beads against the side of the tube in seconds, allowing for reproducible purifications to be performed quickly and easily.


For information 978-762-5170

Fluorescent Detection Kit

The DetectX Glutathione Fluorescent Detection Kit is designed to quantitatively measure free and oxidized glutathione in a single sample. The kit makes use of a proprietary molecule, ThioStar, that covalently binds to the free thiol group on glutathione to yield a highly fluorescent product. After mixing the sample with ThioStar for 15 minutes, the user reads the glutathione-generated signal at 510 nm in a fluorescent plate reader. Addition of the provided reaction mixture to the wells converts all the glutathione disulfide into free glutathione, which then reacts with the excess ThioStar during a second 15-minute incubation to detect total glutathione.


For information 734-677-1774

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Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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