PerspectiveMolecular Biology

Dynamic DNA Methylation

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Science  20 Mar 2009:
Vol. 323, Issue 5921, pp. 1568-1569
DOI: 10.1126/science.1172782

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  1. Silenced, again.

    DNA methylation that is lost in previous generations (for example, through mutation of a gene required for methylation) can be restored in subsequent generations when a gene encoding the wild-type version of the protein is reintroduced. However, remethylation is restricted to loci that produce siRNAs, and depends on the RNA-directed DNA methylation pathway. SiRNAs can thus selectively correct methylation defects to enforce silencing. nt, nucleotide.