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Science  05 Jun 2009:
Vol. 324, Issue 5932, pp. 1341
DOI: 10.1126/science.324_1341a

Cell Imaging System

The IN Cell Analyzer 2000 is a flexible cell imaging system for high content analysis with high image quality, speed, and ease of use. The system can perform a wide variety of challenging experiments, from investigative microscopy through automated screening and imaging of organelles, cells, tissues, and whole organisms. New features include rapid preview scanning of a selected area of a sample at any available magnification prior to starting an acquisition run; a high-performance large-chip charge-coupled device camera combined with a widefield illumination source that is twice as bright as a conventional xenon lamp, ensuring statistically robust results in a single pass; and whole-well imaging to capture an entire well in a single image, enhancing the ability to image rare events. A wide range of objectives are available to suit a variety of sensitivity requirements.

CrossBeam Workstation

The Auriga CrossBeam focused ion beam/scanning electron microscope workstation features a new chamber design and unique charge compensation system for advanced analysis. The instrument's redesigned vacuum chamber includes 15 ports for different detectors. Its charge compensation system enables the local application of an inert gas flush. In this way, electrostatic charging of nonconductive samples is neutralized and detection of secondary electrons as well as backscattered electrons becomes feasible. The heart of the workstation is the field emission-scanning electron microscopy column, which enables the analysis of magnetic samples.

Fluorescent Blot Kit

SpectraPlex provides the tools to perform quantitative, two-color fluorescent protein immunoblots. Multicolor detection makes it possible to simultaneously quantify a loading control and a protein of interest or phosphorylated isoforms of a single protein, which greatly increases the information from a single blot while saving time and reagents. The kit includes fluorescently labeled secondary antibodies as well as blocking and washing buffers optimized to provide high sensitivity; as little as 1 pg of protein can be detected. The excitation and emission spectra of the SpectraPlex secondary antibodies are compatible with common fluorescence imaging systems.

Scanning Probe Microscope

The Hydra is designed to open new horizons for the application of atomic force microscopy (AFM) in biology. The ground-up design of the Hydra provides no geometric or optical obstruction or interference either from above or below the scanning probe microscope system. It incorporates a tuning fork feedback mechanism to provide new sensitivities. The Hydra comes with a NanoToolKit of glass-based probes, including transparent AFM probes and nanopipette probes for conductance and structurally correlated patch-clamp applications. The instrument is suitable for all modes of optical microscopy, including standard fluorescence, confocal, total internal reflection fluorescence, fluorescence resonance energy transfer, and differential interference contrast techniques.

Optical Metrology Instrument

The LEXT OLS4000 is the latest version of the LEXT confocal laser scanning microscope metrology system. It offers enhanced functionality, including near-vertical slope capabilities, large optical zoom, and a navigation overview window. Its software brings complex processes within easy reach of a broad range of users. The system has a sleek look and requires only a single control unit. It has been designed with a large and fast scanning mirror along with dual pinholes; the large mirror enables the system to provide superior optical quality, and the increased scan speed halves the time it takes to create a three-dimensional image of a sample. The 405-nm laser and dual pinholes operate simultaneously to ensure that the system provides high resolution and clarity as well as enabling steep slope detection up to 85°, so even the most complex surface topologies can be imaged and analyzed.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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