Report

Ligand-Gated Chloride Channels Are Receptors for Biogenic Amines in C. elegans

Science  03 Jul 2009:
Vol. 325, Issue 5936, pp. 96-100
DOI: 10.1126/science.1169243

You are currently viewing the abstract.

View Full Text
As a service to the community, AAAS/Science has made this article free with registration.

Abstract

Biogenic amines such as serotonin and dopamine are intercellular signaling molecules that function widely as neurotransmitters and neuromodulators. We have identified in the nematode Caenorhabditis elegans three ligand-gated chloride channels that are receptors for biogenic amines: LGC-53 is a high-affinity dopamine receptor, LGC-55 is a high-affinity tyramine receptor, and LGC-40 is a low-affinity serotonin receptor that is also gated by choline and acetylcholine. lgc-55 mutants are defective in a behavior that requires endogenous tyramine, which indicates that this ionotropic tyramine receptor functions in tyramine signaling in vivo. Our studies suggest that direct activation of membrane chloride conductances is a general mechanism of action for biogenic amines in the modulation of C. elegans behavior.

  • * These authors contributed equally to this work.

  • Present address: Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Full Text