Review

Transcriptional Regulatory Circuits: Predicting Numbers from Alphabets

Science  24 Jul 2009:
Vol. 325, Issue 5939, pp. 429-432
DOI: 10.1126/science.1171347

You are currently viewing the abstract.

View Full Text

Abstract

Transcriptional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA) expression levels. With advances in quantitative and high-throughput technologies that allow measurement of gene expression state in different conditions, data that can be used to build and test models of transcriptional regulation is being generated at a rapid pace. Here, we review experimental and computational methods used to derive detailed quantitative circuit models on a small scale and cruder, genome-wide models on a large scale. We discuss the potential of combining small- and large-scale approaches to understand the working and wiring of transcriptional regulatory circuits.

  • * These authors contributed equally to this work.

View Full Text

Cited By...