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Science  07 Aug 2009:
Vol. 325, Issue 5941, pp. 768
DOI: 10.1126/science.325_768a

In Vivo siRNA Delivery

MaxSuppressor RNA-LANCEr II is a nonviral transfection agent optimized for the efficient in vivo introduction of small interfering RNA, microRNA, and other RNA interference (RNAi) agents. The new agent is comprised of a neutral hydrophobic emulsion that encapsulates and delivers RNAi agents directly into tissues. Users simply mix the agent with their RNAi agent, extrude or sonicate the mixture, and inject into an animal. It offers consistent, reliable silencing using minimal amounts of RNAi agents.

Blood miRNA Kit

The PAXgene Blood miRNA Kit lets researchers minimize preanalytical variables for RNA and microRNA (miRNA). PAXgene Blood RNA Tubes used in combination with the new miRNA kit comprise the first system for collecting and stabilizing whole human blood and copurifying total RNA enriched for miRNA. Systems such as the PAXgene Blood RNA System inhibit RNA degradation and gene induction in vitro, resulting in preservation of the gene expression profile that is essential for accurate analysis, but researchers cannot easily extract and purify the miRNA from these samples. The PaxGene Blood miRNA Kit provides this ability. Both manual and automated protocols are available.

Reference Control Tool

The microRNA-specific miRXplore Universal Reference is a synthetic microRNA (miRNA) pool that comprises more than 950 miRNA oligonucleotides from human, mouse, rat, and virus. It allows direct comparison of large numbers of samples, independent of the time of the experiment, and allows the user to save control sample material. The Universal Reference also serves as a hybridization control or as a quality control to monitor miRNA microarray hybridization efficiency. It can also be used as a positive control for real-time polymerase chain reaction, cloning, and sequencing experiments.

Target Expression Vector

The pmirGLO Dual-Luciferase miRNA Target Expression Vector provides researchers in microRNA (miRNA) study both the ability to measure a wide dynamic range of miRNA activity in a vast number of cell types and the option to create a stable cell line from one genetic construct for further research. The pmirGLO vector makes use of optimized firefly luciferase gene as the readout for activity, while also offering a Renilla luciferase/neomycin resistance gene for data normalization. The pmirGLO vector allows a luciferase reporter gene assay to measure the function of endogenous or exogenous miRNA and enables functional studies of sequence variations in 3'-untranslated gene regions.

Transcriptome Tools

The ExactStart tools for transcriptome discovery and analysis enable the user to selectively tag the exact 5¢ end of any class of RNA molecules in a total RNA preparation. The tagged RNA is then converted to complementary DNA (cDNA) with unique tagging sequencing on both ends that are customizable based on the intended application, such as next generation sequencing. Kits are available for small-RNA discovery and analysis, full-length cDNA cloning, and rapid amplification of cDNA ends.

Inert Pipette Tips

High-quality BioClean pipette tips are completely inert and do not influence experimental outcome in any way. They have been tested by independent analysts for the absence of bioactive components and boast a proven lack of external contaminants, including DNA, deoxyribonuclease, ribonuclease, adenosine triphosphate, pyrogens, and polymerase chain reaction inhibitors in the production and packaging process.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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