News of the WeekNuclear Transplantation

Researchers Prevent Inheritance of Faulty Mitochondria in Monkeys

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Science  28 Aug 2009:
Vol. 325, Issue 5944, pp. 1061
DOI: 10.1126/science.325_1061a

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In recent years, scientists have linked numerous cancers and brain diseases to malfunctioning mitochondrial DNA, which may affect up to one in 6000 people. In a paper published online by Nature on 26 August, Shoukhrat Mitalipov's team describes their success in combining nuclear transplantation with in vitro fertilization to interrupt the inheritance of mitochondrial diseases, leading to the birth of healthy twin macaques. Mitalipov says they must wait to see if the monkeys are viable adults before expanding their work to humans.