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Disrupting Hedgehog May Reverse Advanced Cancer, If Only Temporarily

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Science  04 Sep 2009:
Vol. 325, Issue 5945, pp. 1188
DOI: 10.1126/science.325_1188

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In the first clinical proof of its kind, a drug has dramatically shrunk cancerous tumors by disrupting a key genetic pathway. But a study targeting one deadly brain cancer, medulloblastoma, ended in disappointment as the patient's once-tamed tumor quickly developed resistance to the drug and killed him. A separate study published online this week in Science describes the mechanism by which the man's brain tumor developed resistance.