Technical Comments

Comment on “The Dynamic Control of Kiss-and-Run and Vesicular Reuse Probed with Single Nanoparticles”

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Science  18 Sep 2009:
Vol. 325, Issue 5947, pp. 1499
DOI: 10.1126/science.1175790

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Abstract

Zhang et al. (Research Articles, 13 March 2009, p. 1448) reported that synaptic vesicles usually release neurotransmitter through a kiss-and-run mechanism occurring within 1 second but that full collapse of the vesicles becomes more prevalent with repeated stimuli. We report that the kinetics of vesicle retrieval do not change during a stimulus train, with endocytosis occurring in 10 to 15 seconds.

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