Report

Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima

+ See all authors and affiliations

Science  18 Sep 2009:
Vol. 325, Issue 5947, pp. 1544-1549
DOI: 10.1126/science.1174671

You are currently viewing the abstract.

View Full Text

Abstract

Metabolic pathways have traditionally been described in terms of biochemical reactions and metabolites. With the use of structural genomics and systems biology, we generated a three-dimensional reconstruction of the central metabolic network of the bacterium Thermotoga maritima. The network encompassed 478 proteins, of which 120 were determined by experiment and 358 were modeled. Structural analysis revealed that proteins forming the network are dominated by a small number (only 182) of basic shapes (folds) performing diverse but mostly related functions. Most of these folds are already present in the essential core (~30%) of the network, and its expansion by nonessential proteins is achieved with relatively few additional folds. Thus, integration of structural data with networks analysis generates insight into the function, mechanism, and evolution of biological networks.

  • * These authors contributed equally to this work.

  • Present address: Center of Systems Biology, University of Iceland, IS-101 Reykjavik, Iceland.

View Full Text