The Coordinates of Truth

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Science  02 Oct 2009:
Vol. 326, Issue 5949, pp. 53-54
DOI: 10.1126/science.1177637

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The scientific method has driven conceptual inquiry for centuries and still forms the basis of scientific investigation. Yet, the hypothesis-based research paradigm itself has received scant attention recently. Here, I propose an alternative model for this paradigm, based on decision, information, and game theory. Analysis of biomedical research efforts with this model may provide a framework for predicting their likely contributions to knowledge, assessing their impact on human health, and managing research priorities.